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                                                         Andrographis paniculata

Andrographis paniculata.

Other Names:

Andrographis Paniculata, Andrographolide, Bhunimba, Bidara, Carmantina, Carmantine, Chiretta, Chirette Verte, Chirreta, Chuan Xin Lian, Chuanxinlian, Chuan Xin Lin, Creat, Échinacée d’Inde, Fa-Tha-Lai-Jone, Fa-Tha-Lai-Jone, Gubak, Herba Andrographitis, Indian Echinacea, Justicia paniculata, Justicie, Kalamegha, Kalmegh, Kalmegha, Kariyat, King of Bitters, Kirta, Mahalita, Nabin Chanvandi, Poogiphalam, Roi des Amers, Sadilata, Sambilata, Shivaphala, Supari, Takila, Vizra Ufar, Yavatikta.


Andrographis paniculata Wall (family Acanthaceae).grows erect to a height of 30–110 cm (12–43 in) in moist, shady places. The slender stem is dark green, squared in cross-section with longitudinal furrows and wings along the angles. The lance-shaped leaves have hairless blades measuring up to 8 cm (3.1 in) long by 2.5 cm (0.98 in). The small flowers are borne in spreading racemes. The fruit is a capsule around 2 cm (0.79 in) long and a few millimeters wide. It contains many yellow-brown seeds.

Andrographis paniculata is one of the most popular medicinal plants used traditionally for the treatment of array of diseases such as cancer, diabetes, high blood pressure, ulcer, leprosy, bronchitis, skin diseases, flatulence, colic, influenza, dysentery, dyspepsia and malaria for centuries in Asia, America and Africa continents. It possesses several photochemical constituents with unique and interesting biological properties.Extract and pure compounds of the plant have been reported for their anti-microbial, cytotoxicity, anti-protozoan, anti-inflammatory, anti-oxidant, immunostimulant, anti-diabetic, anti-infective, anti-angiogenic, hepato-renal protective, sex hormone/sexual function modulation, liver enzymes modulation insecticidal and toxicity activities. The results of numerous toxicity evaluations of extracts and metabolites isolated from this plant did not show any significant acute toxicity in experimental animal trials.

Andrographis paniculata, commonly known as ‘king of bitters,’ is an herb traditionally used in Ayurveda and Traditional Chinese Medicine.

Andrographis paniculata is used to treat the common cold. It is fairly effective when taken for three to five days after the symptoms first appear. 

Andrographis paniculata has also been studied for its anti-cancer effects. In vitro (outside the body) testing and animal research suggest that Andrographis paniculata has an anti-proliferative effect, meaning it is able to slow the spread of cancer cells. 

The bioactive ingredients of Andrographis paniculata can be traced back to a single diterpene molecule called andrographolide.

Some studies have found that prolonged high-dosage Andrographis paniculata can cause toxicity in the testicles and liver. Further research is needed to confirm these effects, since some follow-up studies, using the same methods, failed to replicate the results. Andrographis paniculata is a promising supplement, though currently it is used most often to alleviate the symptoms of the common cold.


Precautions and contraindications:

Andrographis can cause side effects such as loss of appetite, diarrhea, vomiting, rash, headache, runny nose, and fatigue.

When used in high doses or long-term, andrographis might cause swollen lymph glands, serious allergic reactions, elevations of liver enzymes, and other side effects.


Special Precautions & Warnings:

Infants and children: Andrographis is POSSIBLY SAFE in children when taken by mouth, short-term. Andrographis has been used in combination with other herbs for up to one month.

Pregnancy and breast-feeding: Andrographis is POSSIBLY UNSAFE when taken by mouth during pregnancy. There is a concern that it might cause miscarriages. Not enough is known about the safety of andrographis during breast-feeding. Stay on the safe side, and avoid using andrographis if you are pregnant or breast-feeding.

Fertility problems: Animal research suggests that andrographis might interfere with reproduction, but this hasn’t been shown in people. Nevertheless, if you are having trouble fathering a child or getting pregnant, it’s best not to use andrographis.

“Auto-immune diseases” such as multiple sclerosis (MS), lupus (systemic lupus erythematosus, SLE), rheumatoid arthritis (RA), or other conditions: Andrographis might cause the immune system to become more active, and this could increase the symptoms of auto-immune diseases. If you have one of these conditions, it’s best to avoid using andrographis.

Bleeding conditions: Andrographis might slow blood clotting. This might increase the risk of bleeding or bruising in people with bleeding disorders.

Low blood pressure: Research suggests that andrographis might lower blood pressure. This has not been seen in humans. In theory, however, andrographis might lower pressure too much if taken by people who already have low blood pressure.